Technology Background

Our Technology

AmacaThera has developed a novel hydrogel to deliver localized therapeutics. Our technology is unique. We've demonstrated GMP manufacturability and are conducting human safety testing

Injectable Hydrogel Solution (AmacaGel)

Injectable hydrogel solution

Injectable hydrogel transitions from liquid to gel at body temperature, ensuring drugs stay at the target site for enhanced therapeutic effect

Surgical team in operating room

Platform provides customizable drug release profiles burst, sustained, or combined to meet various clinical needs from post-surgical pain to oncology

The Shoichet Lab

Based in Groundbreaking, Innovative Research

AmacaThera was spun out of The Shoichet Lab as a commercial company in 2016, with support from Toronto's early-stage biotechnology sector.

Versatility and Scalability

developed through innovative research:

Hydrogel close-up

AmacaGel can deliver small molecules, growth factors, antibodies, stem cells, and enzymes

Cell structure close-up

straightforward "mix and fill" process reduces production costs and supports global scalability

Why choose AmacaThera's hydrogel platform?

Feature 1

Targets hard-to-reach sites, including incision areas, brain, and eye tissue, for conditions ranging from post-surgical pain to oncology


Feature 2

Accommodates a broad range of therapeutic modalities, from small molecules and biologics to stem cells and enzymes


Feature 3

Shear-thinning hydrogel enables convenient dosing via pre-filled syringe, integrating smoothly into surgical workflows


Feature 4

Constructed from approved, well-tested materials to minimize risk and support clinical use


Feature 5

Clinically validated, with demonstrated safety and efficacy in both preclinical and phase 1 human trials


Feature 6

Flexible platform for controlled drug delivery to diverse anatomical locations, enhancing dosing and therapeutic outcomes


Feature 7

Strong intellectual property portfolio and readiness for GMP-scale manufacturing